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In assessment of the treatment effect, based on treatment adherence, results from STEP UP showed individuals treated with semaglutide 7.2 mg achieved a superior weight loss of 20.7% after 72 weeks, compared with 17.5% for semaglutide 2.4 mg and 2.4% for placebo
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188 Germline GOF-heterozygous variants have also been reported in the TP53 gene
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