First and foremost, GLP-1 mediated signaling in the brain has a well-established neuroprotective effect, which has been repeatedly proven to enhance memory and cognitive functions, improve neurogenesis and synaptic functions, as well as restore balance in neurotransmission, i.e
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When enough of them break simultaneously, the peptide loses its ability to fit properly into the GLP-1 receptor
a comprehensive exploration of the structure-activity relationship of GLP-1 receptor activation in response to natural GLP-1 (736) amide revealed an extensive interaction of the C-terminus of GLP-1 with the peptide-binding groove of the N-terminal extracellular domain (ECD) of the GLP-1 receptor
