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It has the highest level of clinical evidence (Phase 3 trials, HIV lipodystrophy)

Risk of low blood sugar: Even though medication may suppress your appetite, skipping meals can cause your blood sugar levels to drop to dangerously high levels

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In studies, periods returned to normal after the patients weight loss has stabilized

This has many practical applications, from accelerated injury healing and joint recovery to increased mobility and improved digestive function

In a 3-month randomized controlled study of type 2 diabetes, it was found that the combination of liraglutide and sitagliptin had no effect on the composition of intestinal flora, had no effect on the alpha and beta diversity, but liraglutide resulted in an elevation of deoxycholic acid (DCA) levels, indicating potential modulation of bile acid metabolism (Smits et al., 2021)