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The Enteric Nervous System (ENS), often called the "second brain" of the gut, is an extensive network of neurons embedded in the walls of the digestive tract that can operate independently of the brain and spinal cord

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Bottom line: GLP1s can affect libido via brain and hormone pathways, but the impact varies

If your flu symptoms are mild (cough, body aches, low fever without gastrointestinal involvement), continuing a lower dose may be acceptable

Common reactions include nausea, flushing, appetite suppression, and fatigue

Taken together, these results suggested that sitagliptin may also play a role of ROS scavenger and sitagliptin can prevent the activation of NFB signaling, which is also affected by the decreased ROS level to some extent