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The second mechanism in Tirzepatide (Mounjaro)
The Specialist Pharmacy Service (SPS) and NHS practice guidance advise that when a GLP-1 receptor agonist is introduced, any DPP-4 inhibitor should generally be discontinued due to the mechanistic overlap and lack of additive benefit
The decision to prescribe GLP-1 agonists for adolescents should ultimately be made on a case-by-case basis, considering the individual patients circumstances, the availability of alternative treatments, and the commitment of the healthcare team to provide comprehensive, ongoing care
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Understanding how to support your body's natural GLP-1 production through dietary and lifestyle modifications provides a foundation for metabolic health, though these approaches should not replace medical therapy where indicated