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Thirty-nine genes (26 transcriptional regulators and 13 protein kinases) were associated with the use of alternative nitrogen sources and amino acid biosynthesis (Supplementary Table 1)

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Indeed, OCTN2 has been shown to transport TEA in a Na + -independent manner 15 , albeit much less efficiently than carnitine (0.2-3% transport rate relative to carnitine) 18,23

Reductions in total cholesterol were statistically significantly greater with all oral semaglutide doses compared with placebo for both estimands at weeks 26 and 52, except for the 3-mg dose at week 52 for the trial product estimand (Supplementary Table 5)