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Because the unusual bond formed through the gamma-carboxyl group of glutamate can only be hydrolyzed by one enzyme, gamma-glutamyltranspeptidase, which is present only on the external surfaces of certain cells

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The naturally occurring Growth Hormone Releasing Hormone is manufactured in the brains hypothalamus, a sort of command center, that then sends signals to the pituitary gland as a secretagogue, which regulates how much of the growth hormone the pituitary gland should release

It's also why benzyl alcohol concentration matters a vial that has been contaminated, frozen incorrectly, or stored too long may have degraded benzyl alcohol distribution, reducing its protective effect even if the water looks clear

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Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis