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A tear in the annulus fibrosus, alongside the degeneration of the nucleus pulposus and the breakdown of the cartilage plate, play roles in the degeneration of the intervertebral disc, which can ultimately result in lumbar disc herniation

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acknowledges the Deutsche Forschungsgemeinschaft (DFG) for funding of his own position in the frame of the Heisenberg programme (Grant DE 1431/9-1) and for funding L.L

Marshall LJ, Bailey J, Cassotta M, Herrmann K, Pistollato F (2023) Poor translatability of biomedical research using Animals - A narrative review

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