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Perform a patch test first and discontinue if persistent irritation develops

Metabolism: Clinical and Experimental, 156, Article PMC10705578

Revised: 4/2026 Full Prescribing Information WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

Increasing the length of fatty acids from C16 (palmitate) to C18 or C20 did not result in the desired properties

Biological analyses were performed on serum, measuring folate, vitamin B12, homocysteine, and folate receptor-alpha autoantibodies using radioimmunoassay and mass spectrometry