Pharmacokinetic studies in children have demonstrated higher clearance, a shorter half-life and lower recovery of factor VIII compared to adults [see Clinical Pharmacology (12.3)]
In pancreatic ductal adenocarcinoma (PDAC), pancreatic stellate cells (PSCs) compete with PDAC cells for alanine as a nutrient, PSCs utilize SLC1A4 to rapidly exchange and maintain environmental alanine concentrations
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