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Examples of drugs that are in the latter class include the anti-malarial drugs dapsone and primaquine, as well as rasburicase which is normally used in the treatment tumor lysis syndrome in patients undergoing chemotherapy for hematologic cancers, but has also been used to reduce the hyperuricemia associated with gout

NAC enhances osteogenic differentiation, upregulates GSH levels, and increases the GSH/GSSG (Glutathione disulfide, GSSG) ratio

Overall, these studies have revealed that aspirins reactivity can be increased by structural interactions that increase binding affinity for either steric blocking of enzymatic transformations, or the covalent acetylation of nucleophilic functional groups to render proteins enzymatically dead (Figure 2A)

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