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In GCs, the CaM/CaMKII pathway may mediate the exendin-4 effect, because the inhibitory effect by exendin-4 on GABA currents did not occur when CaM and CaMKII were blocked by W-7 and KN-93, respectively (Fig

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However, insulin remains essential for some patients, particularly those with severe hyperglycaemia or significant beta-cell failure