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When monotherapy is not sufficient, sulfonylureas, meglitinides, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) agonists (liraglutide, exenatide, semaglutide, dulaglutide) or insulin can be combined (171)

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As the typical membrane resistance of GLUTag cells was 2 to 5 G, this would be sufficient to depolarise the cells by approximately 5 to 15 mV, thereby initiating action potential firing and calcium entry

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A peptide that has changed color in its powder form (from white to yellow or brown) is likely degraded