Back Eng, J, Kleinman, WA, Singh, L, et al (April 1992) 'Isolation and characterisation of Exendin-4, an Exendin-3 analogue, from heloderma suspectum venom', The Journal of Biological Chemistry , 267/11, 7402-06
Typical results: Expect losses of anywhere from 21 to 32 percent of body weight, per studies published in Nature Medicine and elsewhere
Retatrutide hits the same receptor, so the same concern applies
Dopamine analogs and somatostatin analogs (SSAs) have been used for medical adjuvant therapies to suppress excessive Gs signaling as activating the Gi/o-coupled dopamine 2 receptor (D2R) or SSTRs, respectively 14
S.et al (2017)
Another reasonable trigger point is when you reach a body fat percentage where the remaining fat is concentrated in specific areas rather than distributed evenly