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Symptom onset typically occurs within the first 24 weeks of treatment or after dose escalation

Background and aims: Insulin clearance figures importantly in glucose metabolism, but its independent relationship with the development of Type 2 diabetes (T2DM) alongside insulin sensitivity and insulin secretion is not known, particularly in older adults who experience greater central adiposity, lower lean mass, and higher cardiometabolic risk

Gastroenterology 144 , S732 (2013)

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It is important to note, as with all drug side effects, that not all people will experience these

4.3 Implications for research, practice, and policy The findings of this network meta-analysis carry important implications for future research, clinical practice, and health policy