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Another systematic review, covering 42 studies, further elucidated the multifaceted role of the microbiome in PCa diagnosis, prognosis and treatment response (25)

In insulin-sensitive states, insulin suppresses gluconeogenesis and promotes glycogen synthesis via PI3K-Akt activation, which inhibits forkhead box O1 (FOXO1), a key transcription factor regulating gluconeogenic enzymes (51)

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