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In Phase 2 trials for diabetes: HbA1c (the standard 3-month blood sugar marker) dropped by around 2.0 percentage points at the higher doses Many patients reached the standard treatment target of HbA1c below 7% Weight loss was preserved alongside the glucose improvements Combining all three receptors means retatrutide can lower blood sugar, encourage weight loss, and improve insulin sensitivity at the same time

doi:10.2337/dc23-1911

Patients with T2D not adequately controlled on therapy with metformin and insulin glargine as baseline therapy received either tirzepatide at the doses used in the SURPASS trials or placebo during the 40-week study setting

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