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The choice depends on whether glucose control or cardiovascular risk reduction is the higher priority for your specific situation

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A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results

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Additionally, by regulating glucose and lipid metabolism and suppressing the HIF-1/VEGF/NF-B pathway, it reduces the accumulation of retinal glycogen and levels of inflammatory factors, protecting the retina from damage induced by high glucose levels (Yin et al., 2021)

it's also about what's not in the vial