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It is unlikely that #retatrutide reaching the 25% weight loss benchmark came as a surprise (link in the comments)

Sometimes it is quantity, with vials containing less material than labeled

The Antidepressant Effects of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis

When a patient watches their glucose response improve in real time on GLP-1 therapy, the reason to keep taking the medication becomes self-evident

For example, a person with a severe allergy to some dyes or fillers found in commercially available medications might benefit from a compounded version with different ingredients

Postbiotics Support GLP-1 Levels