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Chronic treatment with PARP inhibitors increased NAD + levels and mitochondrial respiration in 10-week-old mice and triggered UPR mt and increased mitochondrial respiration and lifespan in worms 109,257

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Neither compound is FDA-approved for any clinical use

Exposure to Radiation: Radiation from medical imaging (like X-rays and CT scans) or environmental sources (such as UV rays from the sun) generates free radicals

Data adapted from Knig's research group at the University of Vienna