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in addition, higher circulating IGF-1 has been linked with increases in MPS, muscle free fatty acid utilization, and improvements insulin sensitivity (Kraemer et al., 2017), which may explain its often linked importance in exercise training adaptations

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Seminotti B, Zanatta , Ribeiro RT, da Rosa MS, Wyse ATS, Leipnitz G, Wajner M (2019) Disruption of brain redox homeostasis, microglia activation and neuronal damage induced by intracerebroventricular administration of S-adenosylmethionine to developing rats

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