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The peak amplitude of a change in fluorescence induced by GLP-1, GLP-1MK-801 or NMDA was calculated by taking an average of ten datapoints from the baseline ( F 0 ) and subtracting this from an average of ten data points from the peak fluorescence ( F : average amplitude peak average amplitude baseline ), which was normalized by dividing by F 0

Similarly, the SURMOUNT-1 trial demonstrated that participants receiving tirzepatide 15 mg weekly lost approximately 20.9% of body weight, with lean mass comprising roughly 25-30% of total loss based on available data

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