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Therefore, we hypothesized that GLP-1 and its metabolites affect peripheral pain regulation through the TRPV1 channel (Fig

Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]

PMID: 8551864 Bowers, C.Y., et al

The NTS itself contains GLP-1 producing neurons which signal to decrease food-based reward in the mesolimbic VTA and NAc, which in turn impact memory and emotional processing in the hippocampus and amygdala [40]

GLP-1 agonists may be used alone in patients intolerant of metformin or in combination with metformin, thiazolidinediones, and sulfonylureas (or in any combination thereof)

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