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In addition to its critical role in the survival of sensory neurons and neurite outgrowth, NGF signalling is also involved in nociception by activating nociceptive neurons, which express high-affinity NGF receptors [27]

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The PBAC will discuss this issue at its November 2025 meeting and provide advice to the Minister by end 2025. In a separate notification, the TGA also flagged it has issued 10 infringement notices to telehealth operator Midnight Health Pty Ltd for the alleged unlawful advertising of prescription-only weight-loss medicines

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A minor pathway of metabolism is the CYP-mediated formation of the toxic product NAPQI which is subsequently inactivated by glutathione conjugation