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Ann N Y Acad Sci 959(1):275284

Namely, they found that the common GLP1R variant Gly168Ser (rs6923761) was associated with poorer response, while rare variants in ARRB1 (notably Thr370Met) enhanced response by reducing GLP1R internalisation and boosting cAMP and insulin secretion, with stronger effects in Hispanic and American Indian/Alaska Native populations

That is, they are effective at reducing A1C with a low risk of hypoglycemia and fewer side effects

Otherwise, electronic damage may occur

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Your body can feel the effects of a boosted metabolism as your energy increases, contributing to an increased rate of calorie burning daily