20 ADMA is an endogenous nitric oxide synthase (NOS) inhibitor that can significantly reduce the synthesis of vasodilator NO, leading to the development of cardiovascular disease
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While the treatment for pruritus stemming from cholestatic liver disorders is established, pruritus originating from non-cholestatic causes is frequently encountered in cirrhotic patients due to various non-cholestatic factors
Clayton AH, Althof SE, Kingsberg S, DeRogatis LR, Kroll R, Goldstein I, Kaminetsky J, Spana C, Lucas J, Jordan R, Portman DJ