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''It wasn't really having an effect, but also the cost was a factor because there were other ingredients in the formulation that from a fat-reduction perspective were more effective,'' says Phosphagenics' chief scientific officer, Paul Gavin

Key finding: Genetic NNMT knockdown increased energy expenditure, reduced adipose tissue by 30% , and elevated NAD+ and SAM levels validating NNMT as a high-value target

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10.1007/s13300-025-01726-7 78 TanW.ChenJ.WangY.XiangK.LuX.HanQ.et al (2024)