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NAD + is also involved in nucleotide and amino acid synthesis, such as the folate-dependent serine catabolism 347 , as well as genomic DNA replication, as reviewed above 118

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Cells increase their contraction of F-actin in response to extracellular forces and remodel their entire cytoskeleton through a process involving Rho-GTPases (such as Rho or Rac1), myosin activity, and ROCK19