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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

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doi: 10.1016/j.jneuroim.2015.05.021 143 MontalbanXHauserSLKapposLArnoldDLBar-OrAComiGet al

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half-life: ~30 min2 hours Plasma levels decline ~60% with age (~200 ng/mL at age 20 ~80 ng/mL at age 60) Influences expression of ~31% of studied human genes linked to repair and regeneration Stimulates collagen type I and III synthesis by up to 70% in studied models Activates fibroblasts