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Magnesium has a mild stool-softening effect and is generally well-tolerated

Given the agency's recent history of granting Priority Review to novel obesity agents with breakthrough designation potential, a six-month review clock would place a potential approval in the first half of 2026

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[8] [9] Lean muscle mass loss : Significant weight reduction may include loss of lean tissue, which could have implications for long-term metabolic health and physical function, particularly in older adults

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The decision should always weigh patient response , cost, and long-term treatment sustainability