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O'Sullivan JDB, Nicu C, Picard M, et al

Additional research is needed to better understand the long-term health outcomes, ideal patient selection and the full scope of risks and benefits for people with T1D who use these medications

Because the two routes differ enormously in absorption

Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision