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The headline weight-loss numbers Analyzed by planned treatment, mean body-weight change from baseline to week 46 was dose-dependent: about 6.2% at 0.6 mg, 12.5% at 2.4 mg, 13.2% at 3.6 mg, and 14.9% at the top 4.8 mg dose, compared with roughly 2.8% for placebo

DAgostino, I., Tacconelli, S., Bruno, A., Contursi, A., Mucci, L., Hu, X., Xie, Y., Chakraborty, R., Jain, K., Sacco, A., Zucchelli, M., Landolfi, R., Dovizio, M., Falcone, L., Ballerini, P., Hwa, J., & Patrignani, P

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It does not have the RCT evidence base that retinoids, niacinamide, or even hyaluronic acid carry

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Caution: If you are pregnant or breastfeeding, or have a liver disease, a kidney disease, or a seizure disorder, consult a healthcare practitioner prior to use