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Introduction Hepatocyte growth factor (HGF) is a pleiotropic cytokine isolated as a potent cell motility factor for epithelial cells (Stoker et al., 1987) and as a strong mitogen for hepatocytes in primary cultures (Nakamura et al., 1989)

Therapeutic implications: context-specific applications The efficacy of antiangiogenic therapies is highly dependent on their application in the appropriate pathological contexts