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with vehicle B [65% D5W (5% dextrose in water), 5% Tween-80, 30% PEG-400], 2) Tamoxifen group with 30 mg/kg Tamoxifen dissolved in vehicle A (oral gavage), 3) Tamoxifen + IKE group with 30 mg/kg Tamoxifen (oral gavage) every three days and daily i.p

IV Glutathione reductase GR the recycling enzyme An NADPH-dependent enzyme that converts GSSG back to two GSH molecules