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Impairment in the control of mitochondrial membrane permeabilization, by mPTP, has been suggested to be responsible for the mitophagy of depolarized mitochondria, induction of apoptosis, and necrosis ( 2+ homeostasis is regulated by different proteins, enzymes, and cellular signaling networks, which may be risk pathways for mood disorders when they are altered ( The maintenance of a healthy mitochondrial pool is critically regulated by the dynamics and turnover of the mitochondrial population ( A considerable amount of literature has demonstrated that neuronal activity regulates mitochondria and synapses ( Mitochondria also regulate synaptic plasticity by transducing some of the effects of glutamate and BDNF