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Rubber stoppers are rated for a limited number of punctures pharmaceutical literature describes approximately 10-25 punctures with standard gauge needles before coring risk increases significantly

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Knezevic M., Gojkovic S., Krezic I., Zizek H., Vranes H., Malekinusic D., Vrdoljak B., Knezevic T., Pavlov K.H., Drmic D., et al