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coli and purified to near homogeneity (see Methods)

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This stability contributes to its practical utility in research settings where consistent dosing matters

Elevated CHOP disrupts apoptotic homeostasis by downregulating anti-apoptotic proteins (e.g., Bcl-2) and upregulating pro-apoptotic proteins (e.g., Bim), while simultaneously impairing the adaptive UPR, collectively driving dopaminergic neuron apoptosis in PD (18)