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Orforglipron (Eli Lilly) is the first non-peptide oral GLP-1 receptor agonist a small molecule rather than an injected peptide, with no SNAC absorption-enhancer required and an FDA decision is anticipated in 2026

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Leptin, in particular, plays a crucial role in signalling energy availability to the brain

doi: 10.1186/s12931-022-02135-1 73

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These factors create a metabolic environment where weight loss is genuinely harder than for women without PCOS