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Yes, especially when you first start the medication or increase your dose

in this context, estrogen supplementation can prevent or reduce these negative features

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Your dose may increase gradually over weeks or months as your provider adjusts your therapya process called titration

reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

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