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The findings also suggest that GLP-1 drugs arent as effective in the real world as they are in clinical trials, the researchers say

For example, liraglutide 1.2 mg and exenatide BID are recommended for use in triple therapy with metformin and SU/TZD if HbA1c 7.5%, body mass index (BMI) 35 kg/m 2 and the patient has psychological or medical problems associated with high body weight, or if BMI 1.5% from target), a GLP-1RA is often recommended over a DPP-4 inhibitor attributable to superior glycaemic efficacy, particularly if the patient is overweight

Paraxanthine has been shown to increase BDNF levels to a greater extend compared to caffeine in a preclinical study [10], which translated in increased cognitive performance in a clinical study investigating the ability to shift between tasks [34]

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