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Moreover, pharmacokinetic constraints may help explain the heterogeneous clinical findings

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analyzed by HS-AFM structural dynamics of intrinsically disordered, barrier-forming phenylalanine-glycine nucleoporins (FG Nups) within the nuclear pore complexes (NPCs) from the Xenopus laevis oocyte and showed that FG Nups are highly flexible and dynamically fluctuating chains that rapidly elongate and retract, consistent with the diffusive motion of tethered polypeptide chains (Sakiyama et al., 2016)