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In the GLP-1 agonist group the mean (SD) age was 55.3 (12.3), 3933 (63%) female, 4554 (72.9%) white, while in the control group the mean (SD) age was 55.5 (13.5), 4025 (64.5%) female, and 4511 (72.3%) white

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[56] This downregulation restores normal leptin signaling pathways (such as the JAK/STAT cascade), effectively re-establishing proper appetite control and reducing energy intake

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