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At the time of synthesis, the C-terminal glycine of a proportion of GLP-1 737 is removed by a peptide amidating monooxygenase to generate GLP-1 736 amide [8]
10.1097/CM9.0000000000001705 16 DongF.DengD.ChenH.ChengW.LiQ.LuoR.et al (2015)
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The peptide has demonstrated efficacy in normalizing pathological blood pressure states, reversing hypertension induced by NOS inhibitors and attenuating hypotension induced by excessive NO substrate administration, indicating adaptive vascular regulation
These metabolic regulations meet the high glutamine demand of proliferating tumor cells, which supports tumor growth by facilitating both energy production and the biosynthesis of building materials