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Inclusion and ethics statement The study presented here, has been approved and annually reviewed by the ethics board of the Ministry of Health of the Democratic Republic of the Congo (DRC) and the IRB board of the Oregon Health and Sciences University

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Most people experience occasional constipation, but about 14% of adults suffer from chronic constipation

There are two sources for increased [Ca 2+ ] i : the influx of extracellular Ca 2+ through voltage-gated Ca 2+ channels on the plasma membrane, and intracellular Ca 2+ pools

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