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03 Research Highlights Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade 04 Dosage Administration & Timing Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue

Inadequate protein during a caloric deficit leads to muscle loss rather than fat loss, defeats the purpose of the protocol, and creates the metabolic slowdown that causes weight loss plateaus

Anatomical changes, though modest overall, were observed in the INL (1-month) or IPL (3-4 months), consistent with results from 1-week and 2-week postexposure tissues 42

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Acute exposure to cigarette smoke decreases available glutathione and macrophage-dependent efferocytosis