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The dichloroquinoxaline group extends to ICL3 forming nonpolar interactions with K346 6.35b , C347 6.36b and a cholesterol molecule in TM6, introduction of electron-donating substituents or replacement of quinoxalines by benzimidazole or quinoline at C-6 and C-7 positions led to poor tolerance 38

Elmsford N

10.1016/j.jpain.2021.03.142 3 AllahdadiK

Dremza., A.M

But the degree of risk differs

Inflammation: Gastrointestinal distress triggers an inflammatory response, activating the coagulation system and increasing the risk of clot formation