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By reducing SAM consumption through NNMT inhibition, 5-Amino-1MQ helps preserve methylation capacity for other critical cellular processes, including DNA and histone methylation (epigenetic regulation), neurotransmitter synthesis, and phospholipid metabolism

When macrophages and other immune cells engulf pathogens or damaged tissue debris, they generate large amounts of ROS, such as superoxide anions, hydrogen peroxide, via respiratory burst (148)

[60 ]Later in vitro and in vivo research, and well documented case reports, 63 suggest a vitamin C dose much higher than that used in the Pauling/Cameron studies can actually be cytotoxic to tumors without damaging normal cells

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Any failure to repair DSBs could lead to gross chromosomal rearrangements, neoplastic transformation of cells, and oncogenesis 1