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Per ADA 2026 Standards of Care, treatment is individualized based on A1C targets, comorbidities (CVD, CKD, heart failure), hypoglycemia risk, weight effects, cost, and patient preference

The authors use this rationale cautiously to reconcile the mismatch between improved cognition and reduced brain volume, stating A clearance and subsequent shifts in cerebrospinal fluid may therefore have also partially explained their findings

doi: Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

The EASL-Lancet liver commission: protecting the next generation of Europeans against liver disease complications and premature mortality