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The ICR mice were used to establish an AD model in vivo , while PC12 cells (treated with A25-35) were used to build an in vitro AD model

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Combination produces well-formed functional vessels rather than pathological leaky vessels

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It has been proposed that the pathophysiology of IIM could be attributed to increased cell death, inadequate removal of cell debris, and excessive autoantigens and pro-inflammatory cytokines, which eventually result in over-stimulated immunological and inflammatory responses (152)