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In the Siamese breed, a genetic component may contribute
The European Food Safety Authority (EFSA) between 2011 and 2012 classified an NOAEL (No Observable Adverse Effect Level) of 0.25 mg/kg BW/day for BHT and 1.0 mg/kg BW/day for BHA in terms of daily intake and admitted that the exposure of adults and children was unlikely to exceed these doses
Fletcher MA, Maher KJ, Klimas NG
Rorat T
On the other hand, it can make adherence harder for those trying to maintain a calorie deficit
Protein-sulfenic and glutathione sulfenic acids result from reaction with endogenously produced ROS or RNS but usually these species are rapidly transformed in prot-SSG (GSSR) or GSSG as more stable derivatives
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